Altered apoptotic protein expressions characterize the survival of Bcr-Abl-independent drug-resistant chronic myeloid leukemia cell line

Apoptosis is a programmed cellular process that occurs in pathological and physiological pathways it one of the most studied topics cell biology. To understand underlying mechanism apoptosis plays an important role molecular pathogenesis many diseases including cancers. Chronic myeloid leukemia (CML) clonal myeloproliferative malignancy arising from neoplastic transformation hematopoietic stem cell. Here, we used Bcr-Abl-independent, imatinib-resistant K562 subpopulation (K562-IR) generated characterized earlier our laboratory. We showed proteins Bcl-2, Bim, RIP, p-MAPK(Erk1/Erk2) NF-кB which play critical roles death are downregulated, Lamin A/C protein expression upregulated K562-IR derivative cells compared to ancestral cells. Our data provide new information on apoptotic molecules Bcr-Abl-independent CML line.